Fri May 30 2025

81 articles - From Friday May 23 2025 to Friday May 30 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Network Meta-Analysis: Efficacy of Biological Therapies and Small Molecules as Maintenance Therapy in Ulcerative Colitis.

In network meta-analysis, upadacitinib and etrasimod were consistently efficacious as maintenance therapy in UC.

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Clin Gastroenterol Hepatol

GLOBAL EPIDEMIOLOGY OF PRIMARY BILIARY CHOLANGITIS: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS.

The rising prevalence of PBC represents a growing healthcare burden in Western Pacific region. The positive association between latitude and PBC prevalence require further studies.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Effectiveness and Safety of a Second JAK Inhibitor in Ulcerative Colitis: The J2J Multicentre Study.

No cases of death, cancer, or major acute cardiovascular events were reported. A second-line of JAKi provided clinical remission in about half of patients after induction, and was well tolerated.

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Functional Dyspepsia and Its Subgroups: Prevalence and Impact in the Rome IV Global Epidemiology Study.

Rome IV FD is one of the most prevalent DGBI globally. Across countries, it is associated with female sex, younger age, psychological distress, reduced quality of life, and higher health care utilisation. PDS is the dominant subgroup. Overlapping other DGBI are present in a minority.

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Late Diagnosis of Chronic Hepatitis B in the United States: A Population-Based, Retrospective Cohort Study From 2007 to 2021.

Approximately three-fourths of patients diagnosed with CHB in the USA had a late diagnosis. Increased screening efforts must be made to prevent poor clinical outcomes.

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Am J Gastroenterol

Effect of 3-day linaclotide administration to reduce the PEG volume for colonoscopy bowel preparation: A multicenter, noninferiority, randomized controlled trial.

The adequate bowel preparation rate of the combination of 3-day linaclotide and 2 L PEG was neither inferior to the combination of 3-day linaclotide and 3 L PEG nor 3 L PEG alone in the average-risk population.

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Overlap of esophageal disorders of gut-brain interactions (E-DGBIs) and GERD is highly prevalent in patients with refractory reflux symptoms.

E-DGBIs are highly prevalent in patients with proven GERD and refractory reflux symptoms. Studies with outcome data are needed to determine whether patients with overlapping E-DGBIs and GERD should be identified with pH-impedance monitoring on PPI therapy before an interventional treatment option is considered.

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The Augmented Colonoscopy with Computer-Aided polyp Characterization (AC-CADx) study - prospective study comparing the diagnostic reliability of optical diagnosis of trainees with experts without AI.

OD of rectosigmoid polyps by trainee endoscopists with CADx is highly accurate, fulfilling PIVI 2 "diagnose-and-leave" strategy.

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Clin Gastroenterol Hepatol

Effect of cecal intubation rate on post colonoscopy colorectal cancer deaths and detection of colorectal cancer precursors.

the endoscopist's cecal intubation rate is strongly associated with their ability to detect adenomas and proximal serrated polyps. A CIR of 95-100% was associated with the lowest hazards for PCCRC death. Based on this data, a CIR above 95% is the desirable target.

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PErsistence and safety of subcutaneous infliximab 1 year after switch from intravenous route in IBD patients in REMission.

In this large multicenter prospective cohort, persistence at one year of SC-IFX was more than 95% of IBD patients switched in remission from IV-IFX, confirming excellent effectiveness and tolerance of SC-IFX.

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Performance of a smartphone-based stool test for use in colorectal cancer screening: population-based study.

The smartphone-based FIT could serve as an alternative in addition to currently offered laboratory FITs. drks.de, DRKS00008737.

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Symptoms of Constipation: Relationship between questionnaires and diaries and Impact on Quality of Life.

Disparities exist between bowel symptoms recorded with questionnaires and diaries. Bowel diaries characterize constipation symptoms in a refined manner; only 52% of participants satisfied constipation symptom criteria on both instruments. Somatic symptoms overshadow the contribution of bowel symptoms to QoL.

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Transferrin Saturation and Serum Ferritin are Main Predictors of Liver Iron Content in Subjects with Hyperferritinemia.

TSAT and serum ferritin allow us to identify more than 95% of patients with a LIC MRI grade 3 and reduce MRI requirements by more than 50%.

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Endoscopy

Identification of 1 mm of preserved muscularis propria on MRI accurately identifies early rectal cancers suitable for local excision in the intermuscular plane.

Use of mrSRT to identify ≥1mm of preserved muscularis propria on MRI allows radiologists to assist in appropriate case selection for EID.

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Prospective analysis of endoscopic impedance planimetry pyloric measurements and its association with clinical outcomes with gastric peroral endoscopic myotomy.

Sustained improvement in pyloric FLIP measurements was seen in patients who endorsed a clinical response to G-POEM. Patients who responded to G-POEM had a lower baseline DI when compared to non-responders. Additional studies optimizing and standardizing FLIP protocols in patients undergoing G-POEM are needed.

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The value of Cholangioscopy-guided Bite-on-Bite (-on Bite) biopsies in Indeterminate Biliary Duct Strictures.

BBB did not outperform at least four single biopsies for IBDS. Prior manipulation of IBDS, through stent placement or prior tissue acquisition, was associated with a decreased diagnostic yield.

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Gastroenterology

Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition.

Fidaxomicin inhibits intestinal fibrosis by reducing PDGFRβ phosphorylation and expression, GSK3β phosphorylation, and collagen expression in intestinal fibroblasts.

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The Role of Artificial Intelligence in Chronic Liver Diseases and Liver Transplantation.

Prospective evaluation of AI tools seamlessly integrated into workflows, especially through clinical trials, as well as patient partner and clinical stakeholder engagement will be key to building trust in the individualized predictions provided. In this review, we delve into the AI literature in hepatology for diagnostic, prognostic and therapeutic applications.

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Gastrointest Endosc

The 2024 top 10 list of endoscopy topics in medical publishing: an annual review by the American Society for Gastrointestinal Endoscopy Editorial Board.

The top 10 identified topics collectively represent advances in the following endoscopic areas: glucagon-like peptide-1 receptor agonists and endoscopy, advances in AI in endoscopy, ergonomics in endoscopy, peroral endoscopic myotomy, bariatric and metabolic endoscopy, endoscopic resection in the colon, gastric intestinal metaplasia and endoscopy, inflammatory bowel disease and endoscopy, GI bleeding risk stratification and endoscopic therapies, and therapeutic EUS. Board members were assigned a topic area and summarized relevant and important articles, thereby generating this overview of the "top 10" endoscopic advances of 2024.

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Hepatology

Galectin-1 modulates glycolysis via a GM1-galactose-dependent pathway to promote hyperthermia resistance in hepatocellular carcinoma.

Gal-1 can mediate hyperthermia resistance in HCC and can potentially be modulated as a therapeutic target to reduce rapid progression after thermal ablation.

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J Hepatol

A non-inferiority randomised controlled trial of a Shorter Acetylcysteine Regimen for Paracetamol Overdose - the SARPO trial.

The shorter 12h acetylcysteine regimen had the same effectiveness and safety as the standard 20h regimen in acute paracetamol overdoses ≤30g, almost halving the length of treatment required.

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Cause-specific mortality in patients with steatotic liver disease in the United States.

CVD and extrahepatic cancer were leading causes of death across SLD subtypes without cirrhosis, while liver- and CVD-related deaths predominated in cirrhosis. MetALD and ALD were associated with progressively higher risks of liver-related mortality compared with MASLD. These findings underscore the need for integrated strategies addressing alcohol use, cardiovascular risk, and cancer screening to reduce preventable deaths. Impact and implications Causes of death across the steatotic liver disease spectrum remains incompletely characterized in routine clinical settings. In this large nationwide cohort study, we evaluated cause-specific mortality in patients with MASLD, MetALD, and ALD. We showed that cardiovascular disease and extrahepatic cancer were the primary causes of death in patients without cirrhosis across SLD subtypes, while liver disease and cardiovascular disease were predominant in those with cirrhosis. Importantly, MetALD and ALD were associated with progressively increasing risks of liver-related mortality compared to MASLD. Our findings highlight the need for integrated care models that simultaneously addresses cardiovascular risk factors, implements strategies to reduce alcohol consumption, and promotes cancer screening to mitigate preventable deaths in SLD.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Breath Profiling in MASLD-A Step Towards Better Risk Stratification.

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Clin Gastroenterol Hepatol

Bias in the Bowels: Disparities Exist in Constipation Testing in a Diverse Patient Cohort.

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Blue Notes.

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Gastroenterology

Presentation of the Julius M. Friedenwald Medal to David Lieberman, MD, AGAF.

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J Hepatol

Enteronephrohepatic Circulation of Bile Acids and Therapeutic Potential of Systemic Bile Acid Transporter Inhibitors.

We also discuss the therapeutic potential of inhibiting the kidney apical sodium-dependent bile acid transporter (ASBT) to redirect bile acids into urine for elimination, reduce hepatobiliary accumulation and systemic levels of bile acids, and treat cholemic nephropathy. In conclusion, a deeper understanding of the enteronephrohepatic bile acid axis is providing insights into novel strategies to protect both liver and kidney in patients with liver disease.

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Immune exclusion in hepatoblastoma: is β-catenin to blame again?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Letter to the Editor.

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Listening Beyond the Symptoms: Existential Needs and Identity in Older Adults With Inflammatory Bowel Disease.

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Response Giuffrè.

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Response to Jia et al.

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Endoscopy

A case of successful endoscopic submucosal dissection of early gastric cancer involving pylorus by switching the direction of traction.

Pubmed   Journal   ReadQx   PMC

A novel biopsy forceps assisted the removal of a deeply displaced pancreatic duct stent with pancreatic duct stenosis under the guidance of a peroral choledochoscope.

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A novel reshapable catheter facilitates selective biliary and pancreatic duct cannulation following endoscopic submucosal dissection including papilla.

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A rare etiology of partial intestinal obstruction and sepsis: idiopathic mesenteric phlebosclerosis.

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An unusual camellia-shaped lesion in a female with diarrhea: beauty is only skin deep.

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Antireflux mucoplasty with the reopenable clip-over-the-line method for refractory gastroesophageal reflux disease.

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Application of "8"-loop traction-assisted duodenal endoscopic submucosal dissection and defect closure.

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Detective flow imaging, directional enhanced blood flow imaging, and contrast-enhanced harmonic endoscopic ultrasound in pancreatic solid lesions.

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Double-snare-assisted endoscopic mucosal resection of a rectal neuroendocrine tumor through a single-channel endoscope.

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Endoscopic injection sclerotherapy with ligation for esophageal varices using single-use endoscope: Report of a video case.

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Endoscopic removal of a large rectal foreign body using an endoscopic retrograde cholangiopancreatography guidewire snare.

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Endoscopic submucosal dissection as an alternative management for huge colon lipoma with acute intussusception.

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Endoscopic ultrasound-guided hepaticogastrostomy using a 22G needle with a 0.018-inch ultra-stiff guidewire without tract dilation.

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Endoscopic ultrasound-guided pancreatic pseudocyst drainage using a novel double-lumen dilator.

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Full-thickness closure using reopenable clip-over-the-line method for a large defect after duodenal full-thickness resection.

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Impact of rotation direction on treating common bile duct stones with an asymmetrical 8-wire helical basket.

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Inhalation of a gastric polyp upon removal.

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Ischemic treatment of the duodenal windsock web using the ultra-thin endoscope, with modified detachable snares.

Pubmed   Journal   ReadQx   PMC

Modified endoscopic purse-string suture with dental floss traction in the management of a duodenal defect.

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Needle-free technique to prevent guidewire damage during endoscopic ultrasound-guided hepaticogastrostomy.

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Noninvasive visualization of neutropenic enterocolitis using capsule endoscopy.

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Organ-preserving endoscopic resection of a large colorectal lesion causing McKittrick-Wheelock syndrome.

Pubmed   Journal   ReadQx   PMC

Risk scores in lower gastrointestinal bleeding - have we reached the stars?

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Successful bridging disconnected pancreatic duct syndrome complicated by plastic stent-induced bowel perforation.

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Successful cold polypectomy for ectopic endometriosis in a narrow distal bile duct using a new slim cholangioscope.

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Successful preoperative esophageal cleansing for achalasia with esophageal dilatation using the drainage method and gel immersion.

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The combination of three advanced endoscopic techniques achieves recanalization of anastomotic stenosis after pancreatogastrostomy.

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The expanding role of endoscopic vacuum therapy.

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Thin therapeutic endoscope combination surgery based clip closure for mucosal defect after colorectal endoscopic submucosal dissection.

Pubmed   Journal   ReadQx   PMC

Troubleshooting for perforation due to proximal metal stent displacement in endoscopic ultrasound-guided hepaticogastrostomy.

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Underwater resection of cecal submucosal tumors using cap, clip, and snare assistance.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

DEVELOPMENT OF ACUTE KIDNEY INJURY IN A PATIENT WITH ALCOHOL-RELATED CIRRHOSIS: THE IMPORTANCE OF DIAGNOSING THE CAUSE OF AKI.

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Gastric Cancer Prevention in the United States: A Work in Progress.

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Gut

A rare cause of long-segment colitis.

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Skin lesions and chest pain in a patient with Crohn's disease.

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J Hepatol

Autologous macrophage therapy for compensated cirrhosis, some hope at the horizon.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: Supporting the Role of Enzyme Therapy in Management of Coeliac Disease-Authors' Reply.

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Letter: Supporting the Role of Enzyme Therapy in Management of Coeliac Disease.

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Clin Gastroenterol Hepatol

Reply letter to Matheus Souza et al.

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Gastroenterology

Analysis of the Article "Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood".

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Can HRME Be Widely Adopted for Esophageal Cancer Screening in Low-Resource Settings?

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Patient Involvement and Methodological Considerations in the UGIC Endoscopy Screening Cluster Trial.

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Regarding"Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood".

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Reimagining HRME's Global Role: Operator Expertise Gap Undermines Cost-Effective ESCN Screening.

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Gut

Validation of the definition of gastro-oesophageal junctional zone: an immunohistochemical study using resected mucosal specimens.

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J Hepatol

EUS-guided portal pressure measurement and thrombosis risk: One swallow does not make a summer ….!

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Is MetALD an all-inclusive term for liver disease caused by alcohol and metabolic dysfunction?

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NUC-1031 in aBTC: a cautionary tale in accelerated drug development.

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Phosphatidylethanol-guided reclassification of steatotic liver disease subgroups improves prognostic stratification: Greater precision is required.

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