81 articles - From Friday May 23 2025 to Friday May 30 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
GLOBAL EPIDEMIOLOGY OF PRIMARY BILIARY CHOLANGITIS: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS. The rising prevalence of PBC represents a growing healthcare burden in Western Pacific region. The positive association between latitude and PBC prevalence require further studies. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Effectiveness and Safety of a Second JAK Inhibitor in Ulcerative Colitis: The J2J Multicentre Study. No cases of death, cancer, or major acute cardiovascular events were reported. A second-line of JAKi provided clinical remission in about half of patients after induction, and was well tolerated. |
Functional Dyspepsia and Its Subgroups: Prevalence and Impact in the Rome IV Global Epidemiology Study. Rome IV FD is one of the most prevalent DGBI globally. Across countries, it is associated with female sex, younger age, psychological distress, reduced quality of life, and higher health care utilisation. PDS is the dominant subgroup. Overlapping other DGBI are present in a minority. |
Late Diagnosis of Chronic Hepatitis B in the United States: A Population-Based, Retrospective Cohort Study From 2007 to 2021. Approximately three-fourths of patients diagnosed with CHB in the USA had a late diagnosis. Increased screening efforts must be made to prevent poor clinical outcomes. |
| Am J Gastroenterol |
Effect of 3-day linaclotide administration to reduce the PEG volume for colonoscopy bowel preparation: A multicenter, noninferiority, randomized controlled trial. The adequate bowel preparation rate of the combination of 3-day linaclotide and 2 L PEG was neither inferior to the combination of 3-day linaclotide and 3 L PEG nor 3 L PEG alone in the average-risk population. |
Overlap of esophageal disorders of gut-brain interactions (E-DGBIs) and GERD is highly prevalent in patients with refractory reflux symptoms. E-DGBIs are highly prevalent in patients with proven GERD and refractory reflux symptoms. Studies with outcome data are needed to determine whether patients with overlapping E-DGBIs and GERD should be identified with pH-impedance monitoring on PPI therapy before an interventional treatment option is considered. |
The Augmented Colonoscopy with Computer-Aided polyp Characterization (AC-CADx) study - prospective study comparing the diagnostic reliability of optical diagnosis of trainees with experts without AI. OD of rectosigmoid polyps by trainee endoscopists with CADx is highly accurate, fulfilling PIVI 2 "diagnose-and-leave" strategy. |
| Clin Gastroenterol Hepatol |
Effect of cecal intubation rate on post colonoscopy colorectal cancer deaths and detection of colorectal cancer precursors. the endoscopist's cecal intubation rate is strongly associated with their ability to detect adenomas and proximal serrated polyps. A CIR of 95-100% was associated with the lowest hazards for PCCRC death. Based on this data, a CIR above 95% is the desirable target. |
PErsistence and safety of subcutaneous infliximab 1 year after switch from intravenous route in IBD patients in REMission. In this large multicenter prospective cohort, persistence at one year of SC-IFX was more than 95% of IBD patients switched in remission from IV-IFX, confirming excellent effectiveness and tolerance of SC-IFX. |
Symptoms of Constipation: Relationship between questionnaires and diaries and Impact on Quality of Life. Disparities exist between bowel symptoms recorded with questionnaires and diaries. Bowel diaries characterize constipation symptoms in a refined manner; only 52% of participants satisfied constipation symptom criteria on both instruments. Somatic symptoms overshadow the contribution of bowel symptoms to QoL. |
| Endoscopy |
Identification of 1 mm of preserved muscularis propria on MRI accurately identifies early rectal cancers suitable for local excision in the intermuscular plane. Use of mrSRT to identify ≥1mm of preserved muscularis propria on MRI allows radiologists to assist in appropriate case selection for EID. |
Prospective analysis of endoscopic impedance planimetry pyloric measurements and its association with clinical outcomes with gastric peroral endoscopic myotomy. Sustained improvement in pyloric FLIP measurements was seen in patients who endorsed a clinical response to G-POEM. Patients who responded to G-POEM had a lower baseline DI when compared to non-responders. Additional studies optimizing and standardizing FLIP protocols in patients undergoing G-POEM are needed. |
The value of Cholangioscopy-guided Bite-on-Bite (-on Bite) biopsies in Indeterminate Biliary Duct Strictures. BBB did not outperform at least four single biopsies for IBDS. Prior manipulation of IBDS, through stent placement or prior tissue acquisition, was associated with a decreased diagnostic yield. |
| Gastroenterology |
Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition. Fidaxomicin inhibits intestinal fibrosis by reducing PDGFRβ phosphorylation and expression, GSK3β phosphorylation, and collagen expression in intestinal fibroblasts. |
The Role of Artificial Intelligence in Chronic Liver Diseases and Liver Transplantation. Prospective evaluation of AI tools seamlessly integrated into workflows, especially through clinical trials, as well as patient partner and clinical stakeholder engagement will be key to building trust in the individualized predictions provided. In this review, we delve into the AI literature in hepatology for diagnostic, prognostic and therapeutic applications. |
| Gastrointest Endosc |
The 2024 top 10 list of endoscopy topics in medical publishing: an annual review by the American Society for Gastrointestinal Endoscopy Editorial Board. The top 10 identified topics collectively represent advances in the following endoscopic areas: glucagon-like peptide-1 receptor agonists and endoscopy, advances in AI in endoscopy, ergonomics in endoscopy, peroral endoscopic myotomy, bariatric and metabolic endoscopy, endoscopic resection in the colon, gastric intestinal metaplasia and endoscopy, inflammatory bowel disease and endoscopy, GI bleeding risk stratification and endoscopic therapies, and therapeutic EUS. Board members were assigned a topic area and summarized relevant and important articles, thereby generating this overview of the "top 10" endoscopic advances of 2024. |
| Hepatology |
Galectin-1 modulates glycolysis via a GM1-galactose-dependent pathway to promote hyperthermia resistance in hepatocellular carcinoma. Gal-1 can mediate hyperthermia resistance in HCC and can potentially be modulated as a therapeutic target to reduce rapid progression after thermal ablation. |
| J Hepatol |
A non-inferiority randomised controlled trial of a Shorter Acetylcysteine Regimen for Paracetamol Overdose - the SARPO trial. The shorter 12h acetylcysteine regimen had the same effectiveness and safety as the standard 20h regimen in acute paracetamol overdoses ≤30g, almost halving the length of treatment required. |
Cause-specific mortality in patients with steatotic liver disease in the United States. CVD and extrahepatic cancer were leading causes of death across SLD subtypes without cirrhosis, while liver- and CVD-related deaths predominated in cirrhosis. MetALD and ALD were associated with progressively higher risks of liver-related mortality compared with MASLD. These findings underscore the need for integrated strategies addressing alcohol use, cardiovascular risk, and cancer screening to reduce preventable deaths. Impact and implications Causes of death across the steatotic liver disease spectrum remains incompletely characterized in routine clinical settings. In this large nationwide cohort study, we evaluated cause-specific mortality in patients with MASLD, MetALD, and ALD. We showed that cardiovascular disease and extrahepatic cancer were the primary causes of death in patients without cirrhosis across SLD subtypes, while liver disease and cardiovascular disease were predominant in those with cirrhosis. Importantly, MetALD and ALD were associated with progressively increasing risks of liver-related mortality compared to MASLD. Our findings highlight the need for integrated care models that simultaneously addresses cardiovascular risk factors, implements strategies to reduce alcohol consumption, and promotes cancer screening to mitigate preventable deaths in SLD. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| J Hepatol |
Enteronephrohepatic Circulation of Bile Acids and Therapeutic Potential of Systemic Bile Acid Transporter Inhibitors. We also discuss the therapeutic potential of inhibiting the kidney apical sodium-dependent bile acid transporter (ASBT) to redirect bile acids into urine for elimination, reduce hepatobiliary accumulation and systemic levels of bile acids, and treat cholemic nephropathy. In conclusion, a deeper understanding of the enteronephrohepatic bile acid axis is providing insights into novel strategies to protect both liver and kidney in patients with liver disease. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Endoscopy |
| Gastroenterology |
| Gut |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gut |
| J Hepatol |